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ARTICLE
Year : 2003  |  Volume : 10  |  Issue : 1  |  Page : 46-50

The effect of the cyclooxygenase blockers, ibuprofen on the development of glomeruli in Sprague-Dawley rats


Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria

Correspondence Address:
O Akinola
Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos
Nigeria
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Source of Support: None, Conflict of Interest: None


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Cyclo-oxygenase mediated prostaglandins are important determinants of glomerular development and kidney function. Ibuprofen inhibit the enzyme cyclo-oxygenase and thereby block the prostaglandin synthesis in the kidneys. Cyclo-oxygenase exist in two iso-forms (COX-1 and COX-2). It has ben proposed that Non-steroidal anti-inflammatory drugs (NSAIDs) with preferential COX-2 selectivity have fewer renal side effects than drugs with preferential COX-1 selectivity. The significance of this remains unclear since nephrotoxicity is relatively uncommon with ibuprofen and, when present is usually rapidly reversible although, ibuprofen has a higher potency against COX-1 than COX-2. We therefore investigated the effect of ibuprofen on glomerulogenesis in Sprague-Dawley rats. Ibuprofen (22 mg/kg/day) was administered orally from day 10 of gestation to day 15 after parturition. Light microscopic examination of ibuprofen-treated neonatal kidneys show hypoplastic glomeruli. These results suggest that low dose ibuprofen is deleterious to glomerular development.


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