Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 250
  • Home
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2015  |  Volume : 22  |  Issue : 4  |  Page : 209-212

Antithrombin III: Plasma Activity and Reference Range Among Nigerian Blood Donors


1 From the Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Nigeria
2 Department of Surgery, Neurosurgery Unit, College of Medicine, University of Lagos, Nigeria

Correspondence Address:
Vincent Oluseye Osunkalu
From the Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1117-1936.173964

Rights and Permissions

Background: Diagnosis of antithrombin III (ATIII) deficiency as a common cause of thrombophilia is primarily based on the determination of antithrombin levels in plasma using a functional activity assay or an immunological assay, but local reference interval is lacking. Aims: The aim of the present study was to determine pattern of antithrombin activity and local reference intervals for ATIII among Nigerians. Subjects and Methods: A cross-sectional study was carried out among healthy blood donors at the Lagos University Teaching Hospital in Nigeria between the age range 18 and 65 years. Structured questionnaires were applied to obtain demographic and clinical history. Percentage ATIII activity was determined using immunoassay technique. Data were analysed using SPSS version 20.0. Results: One hundred and fifty-five healthy blood donors who participated in this study consisted of 84 males and 71 females. The mean age of participants was 35 ± 6.7 years with a modal age range at 25-49 years. The mean percentage ATIII activity was 91.2 ± 14.2% (confidence interval: 69.2-113.2). Reference interval estimated for all the subjects was 62.8-119.6%. ATIII activity was lower in females compared to males (91.1 vs. 94.2; P = 0.03). However, ATIII activity tended to decrease with increasing age (P = 0.001). Conclusion: Mean percentage ATIII activity for our study population was 91.2% with a reference interval of 62.8-119.6%. Reference interval for ATIII activity in African population is lower than documented Caucasian values.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1997    
    Printed40    
    Emailed0    
    PDF Downloaded235    
    Comments [Add]    

Recommend this journal