Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 423
  • Home
  • Print this page
  • Email this page
REVIEW ARTICLE
Year : 2018  |  Volume : 25  |  Issue : 2  |  Page : 67-72

Pathogenesis, diagnostic challenges and treatment of zika virus disease in resource-limited settings


1 Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria
2 Department of Paediatrics, Jos University Teaching Hospital, Jos, Nigeria
3 Department of Medical Microbiology, Jos University Teaching Hospital, Jos, Nigeria
4 Department of Obstetrics and Gynaecology, Jos University Teaching Hospital, Jos, Nigeria

Correspondence Address:
Nathan Yakubu Shehu
Department of Medicine, Jos University Teaching Hospital, Jos
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/npmj.npmj_36_18

Rights and Permissions

The association of Zika virus (ZIKV) infection with congenital malformation and neurological sequelae has brought significant global concern. Consequently, the World Health Organization (WHO) declared it “a public health emergency of International concern” on 1 February, 2016. A critical review of its pathogenesis would lead to a better understanding of the clinical features and the neurological complications. This review is based on literature search in PubMed/Medline, Google Scholar and the WHO, http://www.who.int. This include all relevant articles written in English published through June 2018, with subject heading and keywords such as Zika, ZIKV, Zika pathogenesis, diagnosis of Zika, Zika Nigeria, Zika Africa and Zika resource-limited settings. Following ZIKV infection, viraemia ensues targeting primarily the monocytes for both the Asian and African strains. ZIKV infection by an African strain appears to be more pathogenic, in early pregnancy tends to result in spontaneous abortion. Whereas an Asian strain tends to be less pathogenic and more chronic, this allows the pregnancy to continue, ultimately resulting in congenital malformations. There is no routine laboratory diagnosis of ZIKV infection in resource-constrained countries. Serologic tests should be interpreted with caution since there can be cross-reactivity with other flaviviruses, especially in Africa where the burden of infection with flaviviruses is comparatively high. There is a paucity of well-equipped laboratories for comprehensive ZIKV diagnosis. It is imperative to strengthen the health systems, improve health workforce and diagnostic capacity of such settings.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed980    
    Printed38    
    Emailed0    
    PDF Downloaded241    
    Comments [Add]    

Recommend this journal