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ORIGINAL ARTICLE
Year : 2019  |  Volume : 26  |  Issue : 2  |  Page : 80-86

Pattern of prevalent Hepatitis B virus genotypes in Zaria, Nigeria


1 Department of Medicine, Ahmadu Bello University, Zaria, Nigeria
2 Department of Medical Laboratory Science, Ahmadu Bello University, Zaria, Nigeria
3 Research Unit, DNA LABS, Kaduna, Nigeria
4 Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria
5 Department of Community Medicine, University of Jos, Jos, Nigeria
6 Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
7 Department of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria
8 Department of Medical Microbiology, Ahmadu Bello University, Zaria, Nigeria

Correspondence Address:
Dr. Abdurrahman Elfulaty Ahmad
Immunology Unit, Department of Medicine, Ahmadu Bello University, Zaria
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/npmj.npmj_59_19

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Background: Hepatitis B virus (HBV) is hyperendemic in Nigeria. Available literature reveal genotype E as being predominant in West Africa. This study aimed at identifying the current pattern and prevalent genotypes of HBV in Zaria, Nigeria. Materials and Methods: Four millilitre of blood was collected in ethylenediaminetetraacetic acid-container from each of 165 HBV surface antigen-positive participants recruited purposively from the gastroenterology clinic from May to August, 2017. Plasma was separated and frozen at −20°C till analysis. Multiplex-nested polymerase chain reaction using type-specific primers was used to identify the various HBV genotypes. Results: Median (and interquartile range) age of the participants was 31.0 (25.5–39.0) years, with males constituting 107 (64.8%). Majority (83.6%) of the samples analysed were HBV-DNA-positive with 82.6% of the HBV-DNA-positive samples being mixed genotype infections. Irrespective of mode of occurrence, five HBV genotypes were identified with HBV/E (97.1%) being the most predominant, followed by HBV/B (82.6%), HBV/A (24.6%), then HBV/C (17.4%), while HBV/D (0.7%) was the least prevalent. Conclusion: In most (99.1%) of the mixed-infection were a combination of genotype E, the predominant genotype, with other genotypes predominantly genotype B. HBV genotypes E, B, A, C and D are the prevalent genotypes in Zaria, Nigeria, as they occur in single genotype and in mixed-genotypes pattern.


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