Nigerian Postgraduate Medical Journal

ORIGINAL ARTICLE
Year
: 2017  |  Volume : 24  |  Issue : 4  |  Page : 245--249

Comparison of efficacy of cell block versus conventional smear study in exudative fluids


Sandeep S Matreja1, Kamal Malukani1, Shirish S Nandedkar2, Amit V Varma1, Anjali Saxena1, Arpita Ajmera1 
1 Department of Pathology, Sri Aurobindo Medical College and PG Institute, Indore, India
2 Department of Pathology, R.D. Gardi Medical College, Ujjain, Madhya Pradesh, India

Correspondence Address:
Dr. Kamal Malukani
Department of Pathology, Sri Aurobindo Medical College and PG Institute, Indore, Madhya Pradesh
India

Introduction: Cytological examination of serous effusions helps in staging, prognostication and management of patients with malignancy. The method has disadvantage of lower sensitivity in differentiating reactive atypical mesothelial cells from malignant cells. Aim: The aim of this study is to compare the cytological features of pleural and peritoneal exudative fluids by conventional smear (CS) method and cell block (CB) method and also to assess the utility of a combined approach for cytodiagnosis of these effusions. Materials and Methods: One hundred and fifty-three pleural and peritoneal exudative fluid samples were subjected to evaluation by both CS and CB methods over a period of 2 years. Cellularity, architecture patterns, morphological features and yield for malignancy were compared, using the two methods. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for diagnosing malignancy were calculated by both methods, using histology as a gold standard. Results: CB method provided higher cellularity, better architectural patterns and additional yield for malignancy as compared to CS method (P < 0.005). Sensitivity, specificity, PPV, NPV, and accuracy by CS method were 69.2%, 95%, 56.25%, 97.08% and 92.8%, while by CB method were 92.30%, 99.2%, 92.30%, 99.28% and 98.6%. Conclusion: The present study shows that it is advisable to routinely make CBs before discarding specimens that are suspicious for malignancy by smear examination.


How to cite this article:
Matreja SS, Malukani K, Nandedkar SS, Varma AV, Saxena A, Ajmera A. Comparison of efficacy of cell block versus conventional smear study in exudative fluids.Niger Postgrad Med J 2017;24:245-249


How to cite this URL:
Matreja SS, Malukani K, Nandedkar SS, Varma AV, Saxena A, Ajmera A. Comparison of efficacy of cell block versus conventional smear study in exudative fluids. Niger Postgrad Med J [serial online] 2017 [cited 2020 Jan 26 ];24:245-249
Available from: http://www.npmj.org/article.asp?issn=1117-1936;year=2017;volume=24;issue=4;spage=245;epage=249;aulast=Matreja;type=0