Nigerian Postgraduate Medical Journal

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 26  |  Issue : 2  |  Page : 80--86

Pattern of prevalent Hepatitis B virus genotypes in Zaria, Nigeria


Abdurrahman Elfulaty Ahmad1, Adamu Girei Bakari1, Bolanle Olufunke Priscilla Musa1, Shettima Kagu Mustapha1, Bello Yusuf Jamoh1, Idris Nasir Abdullahi2, Mohammed Ibrahim Tahir2, Abdulqadri Olarenwaju Olatunji3, Sumayya Hamza Maishanu3, Ahmed Babangida Suleiman4, Afolaranmi Tolulope5, Claudia Hawkins6, Atiene Solomon Sagay7, Ayuba Zoakah5, Adebola Tolulope Olayinka8 
1 Department of Medicine, Ahmadu Bello University, Zaria, Nigeria
2 Department of Medical Laboratory Science, Ahmadu Bello University, Zaria, Nigeria
3 Research Unit, DNA LABS, Kaduna, Nigeria
4 Department of Microbiology, Ahmadu Bello University, Zaria, Nigeria
5 Department of Community Medicine, University of Jos, Jos, Nigeria
6 Department of Medicine, Division of Infectious Diseases, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
7 Department of Obstetrics and Gynaecology, University of Jos, Jos, Nigeria
8 Department of Medical Microbiology, Ahmadu Bello University, Zaria, Nigeria

Correspondence Address:
Dr. Abdurrahman Elfulaty Ahmad
Immunology Unit, Department of Medicine, Ahmadu Bello University, Zaria
Nigeria

Background: Hepatitis B virus (HBV) is hyperendemic in Nigeria. Available literature reveal genotype E as being predominant in West Africa. This study aimed at identifying the current pattern and prevalent genotypes of HBV in Zaria, Nigeria. Materials and Methods: Four millilitre of blood was collected in ethylenediaminetetraacetic acid-container from each of 165 HBV surface antigen-positive participants recruited purposively from the gastroenterology clinic from May to August, 2017. Plasma was separated and frozen at −20°C till analysis. Multiplex-nested polymerase chain reaction using type-specific primers was used to identify the various HBV genotypes. Results: Median (and interquartile range) age of the participants was 31.0 (25.5–39.0) years, with males constituting 107 (64.8%). Majority (83.6%) of the samples analysed were HBV-DNA-positive with 82.6% of the HBV-DNA-positive samples being mixed genotype infections. Irrespective of mode of occurrence, five HBV genotypes were identified with HBV/E (97.1%) being the most predominant, followed by HBV/B (82.6%), HBV/A (24.6%), then HBV/C (17.4%), while HBV/D (0.7%) was the least prevalent. Conclusion: In most (99.1%) of the mixed-infection were a combination of genotype E, the predominant genotype, with other genotypes predominantly genotype B. HBV genotypes E, B, A, C and D are the prevalent genotypes in Zaria, Nigeria, as they occur in single genotype and in mixed-genotypes pattern.


How to cite this article:
Ahmad AE, Bakari AG, Musa BO, Mustapha SK, Jamoh BY, Abdullahi IN, Tahir MI, Olatunji AO, Maishanu SH, Suleiman AB, Tolulope A, Hawkins C, Sagay AS, Zoakah A, Olayinka AT. Pattern of prevalent Hepatitis B virus genotypes in Zaria, Nigeria.Niger Postgrad Med J 2019;26:80-86


How to cite this URL:
Ahmad AE, Bakari AG, Musa BO, Mustapha SK, Jamoh BY, Abdullahi IN, Tahir MI, Olatunji AO, Maishanu SH, Suleiman AB, Tolulope A, Hawkins C, Sagay AS, Zoakah A, Olayinka AT. Pattern of prevalent Hepatitis B virus genotypes in Zaria, Nigeria. Niger Postgrad Med J [serial online] 2019 [cited 2019 Aug 22 ];26:80-86
Available from: http://www.npmj.org/article.asp?issn=1117-1936;year=2019;volume=26;issue=2;spage=80;epage=86;aulast=Ahmad;type=0