Home About us Editorial board Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online: 149
  • Home
  • Print this page
  • Email this page
Year : 2003  |  Volume : 10  |  Issue : 1  |  Page : 46-50

The effect of the cyclooxygenase blockers, ibuprofen on the development of glomeruli in Sprague-Dawley rats

Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria

Correspondence Address:
O Akinola
Department of Anatomy, College of Medicine, University of Lagos, P.M.B. 12003, Lagos
Login to access the Email id

Source of Support: None, Conflict of Interest: None

Rights and PermissionsRights and Permissions

Cyclo-oxygenase mediated prostaglandins are important determinants of glomerular development and kidney function. Ibuprofen inhibit the enzyme cyclo-oxygenase and thereby block the prostaglandin synthesis in the kidneys. Cyclo-oxygenase exist in two iso-forms (COX-1 and COX-2). It has ben proposed that Non-steroidal anti-inflammatory drugs (NSAIDs) with preferential COX-2 selectivity have fewer renal side effects than drugs with preferential COX-1 selectivity. The significance of this remains unclear since nephrotoxicity is relatively uncommon with ibuprofen and, when present is usually rapidly reversible although, ibuprofen has a higher potency against COX-1 than COX-2. We therefore investigated the effect of ibuprofen on glomerulogenesis in Sprague-Dawley rats. Ibuprofen (22 mg/kg/day) was administered orally from day 10 of gestation to day 15 after parturition. Light microscopic examination of ibuprofen-treated neonatal kidneys show hypoplastic glomeruli. These results suggest that low dose ibuprofen is deleterious to glomerular development.

[PDF Not available]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded0    
    Comments [Add]    

Recommend this journal