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Year : 2006  |  Volume : 13  |  Issue : 3  |  Page : 203-205

Effect of cottonseed oil on oestrous cycle and ovulation in albino rats of Wistar strain

Department of Anatomy, College of Medicine, University of Ilorin, P M B 1515, Ilorin, Nigeria

Correspondence Address:
O B Akinola
Department of Anatomy, College of Medicine, University of Ilorin, P M B 1515, Ilorin
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Source of Support: None, Conflict of Interest: None

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OBJECTIVE: The antispermatogenic and contraceptive importance of gossypol had been established in male animals, including man; in the present work, adult female Wistar rats weighing 110 - 160g were used to study the effect of cottonseed oil (gossypol) on oestrous cycle and ovulation. MATERIALS AND METHODS: Forty-five cyclic female rats were sorted randomly into three experimental groups of fifteen animals each. Oral doses of 20 and 40 mg/kg/body weight were administered once a day at 0900 hr for a period of 15 days. Vaginal swab of animals were taken each day between 0700 hr- 0900 hr to study their oestrous cycle; at the end of each cycle (4-5 days), a batch of 5 animals was sacrificed in each group to evaluate the number of ova shed. RESULTS: The results showed that gossypol had no disruptive effects on oestrous cycle; ovulation was not adversely affected, neither was there any significant reduction (p > 0.05) in the number of oocytes released. CONCLUSION: Because gossypol did not alter the oestrous cycle and ovulation patterns in the study animals, we suggest that certain factors exist in female animals that abolish or limit gossypol toxicity; these were extensively discussed.

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