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ARTICLE
Year : 2013  |  Volume : 20  |  Issue : 1  |  Page : 39-44

Influence of ageing process on body composition of antioxidant and lipid peroxidation among healthy individuals in South West Nigeria


1 Department of Chemical Pathology, College of Health Sciences, LadokeAkintola University of Technology, Osogbo; Malaria Research and Clinical Laboratory, College of Health Sciences, LadokeAkintola University of Technology, Osogbo, Nigeria
2 Department of Pharmacology and Therapeutics, College of Health Sciences, LadokeAkintola University of Technology, Osogbo; Malaria Research and Clinical Laboratory, College of Health Sciences, LadokeAkintola University of Technology, Osogbo, Nigeria

Correspondence Address:
P S Ogunro
Department of Chemical Pathology, College of Health Sciences, LadokeAkintola University of Technology, Osogbo; Malaria Research and Clinical Laboratory, College of Health Sciences, LadokeAkintola University of Technology, Osogbo
Nigeria
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Source of Support: None, Conflict of Interest: None


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Aims and objectives: To evaluate the effect of ageing on the level of antioxidants and lipid Peroxidationin healthy individual of various age groups. Subjects and methods: A total number of 162 healthy males and females volunteer between the ages of 18-80years were divided into three groups. These volunteers were divided into group i(18-30yr), group ii (31-60yrs) and group iii (60-80yr). Plasma concentration of total bilirubin, uric acid, ascorbic acid, á-tocopherol, retinol, total antioxidant status(TAS), malondialdehyde (MDA), glutathione (GSH) and ceruloplasmin measured. Erythrocyte antioxidantenzyme activities of superoxide dismutase(SOD), catalase(CAT), glutathione and peroxidase(GSH-Px) were measured using standard methods. Results: Erythrocyte antioxidant enzymes(GSH-Px and SOD) activities and GSH level were significantly reduced among group iii(p<0.01) and group ii (p<0.05) age group subjects compared to the younger age groupi. Conversely,MDA showed a significant increase in group iii (p<0.01) and group ii (p<0.01) compared to younger age group i. CAT activity and TAS level were reduced significantly (p<0.05) in both groups iii and ii compared to younger age group i.Ascorbic acid, á-tocopherol and retinol levels were significantly reduced among group iii (p<0.05) compared to group i. Conclusion: Ageing was associated with increased lipid peroxidation and lower antioxidant defenses. Changes that occur during ageing cannot be avoided but may be delayed and controlled to some extent. To counter these changes, dietary supplementation of a variety of antioxidants might be beneficial.


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