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Year : 2020  |  Volume : 27  |  Issue : 4  |  Page : 325-330

CA125 levels in pregnancy: A case-control study amongst pregnant women in Aminu Kano teaching hospital, North-West Nigeria

1 Department of Obstetrics and Gynaecology, Muhammad Abdullahi Wase Teaching Hospital, Kano, Nigeria
2 Department of Obstetrics and Gynaecology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano, Nigeria
3 Department of Chemical Pathology and Immunology, Faculty of Clinical Sciences, College of Health Sciences, Bayero University, Kano, Nigeria
4 Department of Community Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria

Correspondence Address:
Dr. Idris Usman Takai
Department of Obstetrics and Gynaecology, Aminu Kano Teaching Hospital, Bayero University, Kano
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/npmj.npmj_241_20

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Background: Induction of inflammatory response within the placenta in patients with pre-eclampsia triggers the expression of CA125, thus making CA125 a potential marker reflecting the severity of preeclampsia. Objective: The study was aimed to assess and compare CA125 levels in pre-eclamptics and normotensives. Subjects and Methods: A case–control design was used to study 83 each of the selected pre-eclamptics and normotensives women using a systematic sampling technique. Data were collected using interviewer-administered questionnaire; blood and urine samples were also collected and analysed in the laboratory. Data were summarised using frequencies, percentages, mean ± standard deviation (SD) or median, and range as appropriate. Inferential statistical measures were used to determine the relationship between the outcome and independent variables with a P value set to be statistically significant at ≤0.05. Results: The ages of the pre-eclamptics and normotensives women were found to have a mean ± SD of 29.46 ± 6.92 and 29.70 ± 6.90 years, respectively. More than half 58 (69.9%) of the cases had proteinuria of 3+ (300 mg/dL). Significant difference was statistically (P < 0.01) found in mean serum CA125 levels between women with mild and severe pre-eclampsia with CA125 being more likely to be higher (>50 IU/mL) in severe pre-eclampsia than in mild pre-eclampsia. Conclusion: The study has shown that serum CA125 is elevated in pre-eclamptic pregnancies compared to normotensive pregnancies and the possibility of CA125 being a biomarker of severity and hence may provide information to make an informed choice in early-onset pre-eclampsia to consider conservative management and thus improve perinatal outcome.

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